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DOI: 10.1055/s-2007-992165
© Sonntag Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Apocynum venetum L. - von der traditionellen Droge zum modernen Phytopharmakon
Publikationsverlauf
Publikationsdatum:
18. Juni 2008 (online)

Zusammenfassung
Das Venezianische Hundsgift (Apocynum venetum L.,) wird seit Hunderten von Jahren in China als traditionelles Phytopharmakon zur Behandlung von Bluthochdruck, Nierenentzündungen und Neurasthenie verwendet. In den letzten zwei Jahrzehnten wurden dem mehrjährigen krautartigen Gewächs durch intensive Forschungsarbeiten weitere Wirkungen wie antioxidative, antidepressive, anxiolytische und lipidsenkende Eigenschaften zugesprochen. Dieser Artikel gibt einen kurzen Überblick über den aktuellen Stand der pharmazeutischen und pharmakologischen Forschung.
Summary
Apocynum venetum L., a traditional herbal drug with up-to-date pharmacological effects
The Venetian dogbane (Apocynum venetum L., Apocynaceae) has been used in traditional Eastern medicine for hundreds of years as a tea to treat high blood pressure, nephritis, and neurasthenia. A leaf extract of Apocynum venetum is rich in polyphenolic compounds such as flavonols, flavonoids, and caffeic acid derivatives, which are known to exhibit a variety of pharmacological activities. Intensive research in the past two decades has shown that the perennial shrub possesses many medicinal values including antioxidant, antidepressant, anxiolytic, and lipid-lowering properties. This review gives a brief overview of the current pharmaceutical and pharmacological research of Apocynum venetum.
Schlüsselwörter
Apocynum venetum - Apocynaceae - Hundsgift - Traditionelle Medizin - ZNS - antidepressiv - angstlösend - Pharmakologie
Key words
Apocynum venetum - Apocynaceae - dogbane - traditional medicine - CNS - antidepressant - anxiolytic - pharmacology
Literatur
- 1
Lee KH.
Research and future trends in the pharmaceutical development of medicinal herbs from
Chinese medicine.
Public Health Nutr.
2000;
3
515-522
MissingFormLabel
- 2 Linnâe Cv, Engel-Ledeboer MSJ, Engel H. Carolus Linnaeus Systema Naturae, 1735. Nieuwkoop; B. de Graaf 1964 30
[19]
MissingFormLabel
- 3
Yokozawa T, Kashiwada Y, Hattori M, Chung HY.
Study on the components of luobuma with peroxynitrite-scavenging activity.
Biol Pharm Bull.
2002;
25
748-752
MissingFormLabel
- 4
Woodson RE.
Studies in the Apocynaceae. I. A critical study of the Apocynoideae (with special
reference to the genus Apocynum).
Annals of the Missouri Botanical Garden.
1930;
17
1-172
174-212
MissingFormLabel
- 5 Davis PH (ed.). Flora of Turkey and the East Aegean Islands. Edinburgh; University Press 1978 6
MissingFormLabel
- 6
Wei JM.
Progress in the study on the medical effects of Apocynum venetum (A. lancifolium).
J Tradit Chin Med.
1988;
8
34-36
MissingFormLabel
- 7
Golab T, Trabert CH, Jäger H, Reichstein T.
Die Glykoside der Rhizome von Apocynum cannabinum L. 3. Mitteilung.Glykoside und Aglykone, 208.
Mitteilung. Helvetica Chimica Acta.
1959;
42
2418-2430
MissingFormLabel
- 8
Qian ZN, Song LH, Gu ZL, Chen BQ, et al..
[An experimental observation on the diuretic effect of an extract of luobuma (Apocynum venetum) leaves].
Zhong Yao Tong Bao.
1988;
13
44-46
64
MissingFormLabel
- 9 Hänsel R, Sticher O, Steinegger E. Pharmakognosie - Phytopharmazie. 6 Aufl. Berlin; Springer 1999
MissingFormLabel
- 10
Xiong Q, Fan W, Tezuka Y, Adnyana IK, et al..
Hepatoprotective effect of Apocynum venetum and its active constituents.
Planta Med.
2000;
66
127-133
MissingFormLabel
- 11
Kim D, Yokozawa T, Hattori M, Kadota S, Namba T.
Effects of aqueous extracts of Apocynum venetum leaves on spontaneously hypertensive, renal hypertensive and NaClfed-hypertensive
rats.
J Ethnopharmacol.
2000;
72
53-59
MissingFormLabel
- 12
Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, et al..
Ginkgo biloba extract: Mechanisms and clinical indications.
Archives of Physical Medicine and Rehabilitation.
2000;
81
668-678
MissingFormLabel
- 13
Yokozawa T, Dong E, Kashiwagi H, Kim D, et al..
In vitro and in vivo studies on anti-lipid peroxidation effect of extract from luobuma
leaves.
Natural Medicine.
1997;
51
325-330
MissingFormLabel
- 14
Butterweck V, Jurgenliemk G, Nahrstedt A, Winterhoff H.
Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test.
Planta Med.
2000;
66
3-6
MissingFormLabel
- 15
Butterweck V, Nishibe S, Sasaki T, Uchida M.
Antidepressant effects of Apocynum venetum leaves in a forced swimming test.
Biol Pharm Bull.
2001;
24
848-851
MissingFormLabel
- 16
Gaudiano BA, Miller IW.
Anxiety disorder comobidity in Bipolar I Disorder: relationship to depression severity
and treatment outcome.
Depress Anxiety.
2005;
21
71-77
MissingFormLabel
- 17
Devane CL, Chiao E, Franklin M, Kruep EJ.
Anxiety disorders in the 21st century: status, challenges, opportunities, and comorbidity
with depression.
Am J Manag Care.
2005;
11
S344-353
MissingFormLabel
- 18
Grundmann O, Nakajima J, Seo S, Butterweck V.
Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.
J Ethnopharmacol.
2007;
110
406-411
MissingFormLabel
- 19
Pellow S, Chopin P, File SE, Briley M.
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety
in the rat.
J Neurosci Methods.
1985;
14
149-167
MissingFormLabel
- 20
Boll M, Weber LW, Becker E, Stampfl A.
Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by
reactive carbon tetrachloride metabolites.
Z Naturforsch [C].
2001;
56
649-659
MissingFormLabel
- 21
Ferencikova R, Cervinkova Z, Drahota Z.
Hepatotoxic effect of D-galactosamine and protective role of lipid emulsion.
Physiol Res.
2003;
52
73-78
MissingFormLabel
- 22 Mutschler E, Geisslinger G, Kroemer HK, Schäfer-Korting M. Arzneimittelwirkungen - Lehrbuch der Pharmakologie und Toxikologie. 8. Aufl. Stuttgart; Wissenschaftliche Verlagsgesellschaft 2001: 1168
MissingFormLabel
- 23
Yokozawa T, Nakagawa T.
Inhibitory effects of Luobuma tea and its components against glucose-mediated protein
damage.
Food Chem Toxicol.
2004;
42
975-981
MissingFormLabel
- 24
De Castro WV, Mertens-Talcott S, Rubner A, Butterweck V, Derendorf H.
Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source
of variability in grapefruit juice-drug interaction studies.
J Agric Food Chem.
2006;
54
249-255
MissingFormLabel
- 25
Butterweck V, Derendorf H, Gaus W, Nahrstedt A, Schulz V, Unger M.
Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?.
Planta Med.
2004;
70
784-791
MissingFormLabel
- 26
Kobayashi M, Saitoh H, Seo S, Butterweck V, Nishibe S.
Apocynum venetum extract does not induce CYP3A and P-glycoprotein in rats.
Biol Pharm Bull.
2004;
27
1649-1652
MissingFormLabel
- 27
Karakaya S, El SN, Tas AA.
Antioxidant activity of some foods containing phenolic compounds.
Int J Food Sci Nutr.
2001;
52
501-508
MissingFormLabel
- 28
Vinson JA, Jang J, Dabbagh YA, Serry MM, Cai S.
Plant polyphenols exhibit lipoproteinbound antioxidant activity using an in vitro
oxidation model for heart disease.
J Agric Food Chem.
1995;
43
2798-2799
MissingFormLabel
- 29
Choi JS, Suh SS, Young HS, Park HJ.
Hypolipemic and hypoglycemic activities of Prunus davidiana in high fat-fed rats.
Arch Pharm Res.
1991;
14
44-47
MissingFormLabel
- 30
Tijburg LB, Mattern T, Folts JD, Weisgerber UM, Katan MB.
Tea flavonoids and cardiovascular disease: a review.
Crit Rev Food Sci Nutr.
1997;
37
771-785
MissingFormLabel
- 31
Duffy SJ, Keaney JF, Jr., Holbrook M, Gokce N, et al..
Short- and long-term black tea consumption reverses endothelial dysfunction in patients
with coronary artery disease.
Circulation.
2001;
104
151-156
MissingFormLabel
- 32
Gordon M.
Dietary antioxidants in disease prevention.
Nat Prod Rep.
1996;
13
265-273
MissingFormLabel
- 33
Wang ZY, Huang MT, Ho CT, Chang R, et al..
Inhibitory effect of green tea on the growth of established skin papillomas in mice.
Cancer Res.
1992;
52
6657-6665
MissingFormLabel
- 34
Landau JM, Wang ZY, Yang GY, Ding W, Yang CS.
Inhibition of spontaneous formation of lung tumors and rhabdomyosarcomas in A/J mice
by black and green tea.
Carcinogenesis.
1998;
19
501-507
MissingFormLabel
- 35
Prasad KN, Hovland AR, Cole WC, Prasad KC, et al..
Multiple antioxidants in the prevention and treatment of Alzheimer disease: analysis
of biologic rationale.
Clin Neuropharmacol.
2000;
23
2-13
MissingFormLabel
Dr. Veronika Butterweck
Department of Pharmaceutics
College of Pharmacy
University of Florida
POBox 100494
Gainesville, FL 32608
USA
eMail: butterwk@cop.ufl.edu