Planta Med 2007; 73(13): 1407-1409
DOI: 10.1055/s-2007-990233
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Diterpenes from Cryptomeria japonica Inhibit Androgen Receptor Transcriptional Activity in Prostate Cancer Cells

Wei-Chun Tu1 , Sheng-Yang Wang2 , Shih-Chang Chien1 , Feng-Min Lin1 , Li-Ru Chen1 , Chih-Yang Chiu1 , Pei-Wen Hsiao1
  • 1Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan, R.O.C.
  • 2Department of Forestry, National Chung-Hsing University, Taichung, Taiwan, R.O.C.
Further Information

Publication History

Received: April 10, 2007 Revised: August 26, 2007

Accepted: September 3, 2007

Publication Date:
09 October 2007 (online)

Abstract

We identified eight diterpenes from Cryptomeria japonica (Taxodiaceae), which inhibit the activity of the androgen receptor (AR) in human prostate cancer (PCa) 22Rv1-derived 103E cells. The compounds 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one (2), sugiol (3), ferruginol (4), and 5-epixanthoperol (7) have near 100 % AR inhibition efficacy at concentrations of 10, 5, 25, and 25 μM, respectively. Because these compounds have very similar structures, analysis of their differential activity may aid in the design of inhibitors for PCa treatment.

Abbreviations

AR:androgen receptor

Nil:nilutamide

PCa:prostate cancer

PSA:prostate specific antigen

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Dr. Pei-Wen Hsiao

Agricultural Biotechnology Research Center

Academia Sinica

128 Academia Road, Sec. 2

Nan-Kang

Taipei 115

Taiwan

Republic of China

Phone: +886-2-2651-5747

Fax: +886-2-2785-9360

Email: pwhsiao@gate.sinica.edu.tw

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