Planta Med 2007; 73(13): 1412-1415
DOI: 10.1055/s-2007-990232
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A New Cytotoxic Agent from Solid-State Fermented Mycelium of Antrodia camphorata

Tzong-Huei Lee1 , Ching-Kuo Lee1 , Wan-Lin Tsou2 , Sheng-Yung Liu2 , Mao-Tien Kuo2 , Wu-Che Wen2
  • 1Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan, R.O.C.
  • 2Golden Biotechnology Corporation, Taipei, Taiwan, R.O.C.
Further Information

Publication History

Received: June 6, 2007 Revised: August 28, 2007

Accepted: September 5, 2007

Publication Date:
11 October 2007 (online)

Abstract

Antroquinonol (1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC50 values ranged from 0.13 ± 0.02 to 6.09 ± 0.07 μM.

References

Dr. Wu-Che Wen

5 F. No.27 - 6 Sec.2 Chung Cheng East Rd

Danshuei Town

Golden Biotechnology Corporation

Taipei

Taiwan 251

Republic of China

Phone: +886-2-2808-5538

Fax: +886-2-7703-0103

Email: wwc@goldenbiotech.com.tw