Screening of some Sudanese plants against Mycobacterium tuberculosis

R. A. Hassouna; A. S. Khalid; H. S. Khalid

doi:10.1055/s-2007-986973

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Planta Med 2007; 73 - P_192
DOI: 10.1055/s-2007-986973

Screening of some Sudanese plants against Mycobacterium tuberculosis

RA Hassouna ¹, AS Khalid ², HS Khalid ³

¹Dept. of Microbiology University of Bakht El Roda Universty
²Dept. of Microbiology – University of Nelein
³Medicinal & Aromatic Plants Research Institute – National Centre for Research – P.O Box 11496

Congress Abstract

The paper evaluates the activity of Sudanese plants used in folk-medicine against Mycobacterium tuberculosis. Preliminary screening was carried out using 20 plant extracts. The screening revealed that the petroleum ether extracts were devoid of any activity while the methanolic extracts showed a weak activity. An experiment was designed to compare the in-vitro activity of two drugs of choice for treatment of tuberculosis (streptomycin & rifampcin) with the activity of the plant extracts [1,2]. A series of sensitivity tests were conducted to evaluate the effect of combined therapy, consisting of the methanolic extract of each plant plus streptomycin on M. tuberculosis. The results revealed that thirteen methanolic extracts have a positive effect on Mycobacterium tuberculosis when mixed with Streptomycin. The minimum inhibitory concentration of each extract was determined. The results indicated that the most effective plant extracts are Asphodelus tenuifolius, Nigella sativa and Kigelia africana.

References: [1] Cruickshank, R; Duguid, P.J; Marmion, P.B and Swain, H.A.R (1975) Medicinal Microbiology, Voulme 2, The Practice of Medical Microbiology 12^th Edition. Churchill Livingstone. [2] Khalid, E. Amna, (2003) Personal communication.