Antibacterial and anticandidal activity studies on Sonchus erzincanicus Matthews

D. Yiğit; N. Yiğit; U. Özgen; H. G. Sevindik; A. E. Aktaş

doi:10.1055/s-2007-986969

Planta Medica, Table of Contents

Antibacterial and anticandidal activity studies on Sonchus erzincanicus Matthews

D Yiğit ¹, N Yiğit ², U Özgen ³, HG Sevindik ³, AE Aktaş ⁴

¹Erzincan University, Faculty of Education, Erzincan, 24030, Turkey
²Atatürk University, Health Services Vocational Training School, Medical Laboratory Program, Erzurum, 25070, Turkey
³Atatürk University, Faculty of Pharmacy, Department of Pharmacognosy, Erzurum, 25240, Turkey
⁴Atatürk University, Faculty of Medicine, Microbiology and Clinical Microbiology Department, Erzurum, 25240, Turkey

Abstract

Sonchus erzincanicus (Compositae) is an endemic species for Turkey [1]. Six Sonchus species grow in Turkey and are known as „sütlük, kuzu gevreği, eşek marulu“ in Turkey [2]. It has been found that some Sonchus species contain sesquiterpene lactone glucosides, flavonoids, triterpenes and steroids [3,4]. In this study, the antibacterial and anticandidal activity of aerial parts of Sonchus erzincanicus Matthews methanol extract and fractions (CHCl₃, EtOAc, aqueous) prepared from methanol extract were evaluated against clinical bacterial and Candida strains.

Tested organism	Zone of inhibition (mm)
	Water	MeOH	EtOAc	CHCl ₃
Escherichia coli	10	15	13	14
Staphylococcus aureus	-	10	-	5
Enterobacter aerogenes	-	10	-	-
Candida albicans	-	13	12	13
Candida glabrata	-	10	10	-
Candida parapsilosis	-	-	10	10

Ampicillin (10µg) >19–10mm sensitive Amphotericin B (10µg) >15–10mm sensitive

References: [1] Matthews, V.A. (1975) Sonchus L. Flora of Turkey and the East Aegean Islands, University Pres. Edinburgh, Volume: 5, pp. 690–696 (edited by Davis, P. H.). [2] Akartürk, R. (2001) Şifalı Bitkiler Flora ve Sağlığımız, Orman Genel Müdürlüğü Mensupları Yardımlaşma Vakfı (in Turkish). [3] Helal A.M. et al. (2000) Phytochemistry 53(4), 473–477. [4] Devkota, K.P. (2005). Ph. D. Thesis, Research Institute Of Chemistry/University of Karachi.