Development of commercial mouthwash combined with herbal extracts for anticariogenic activity against Streptococcus mutans

S. Saraya; C. Cheewansirisuk; Y. Wongkrajang; B. Kongsaktrakoon; C. Manamuti; R. Temsiririrkkul

doi:10.1055/s-2007-986909

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Planta Med 2007; 73 - P_128
DOI: 10.1055/s-2007-986909

Development of commercial mouthwash combined with herbal extracts for anticariogenic activity against Streptococcus mutans

S Saraya ¹, C Cheewansirisuk ¹, Y Wongkrajang ¹, B Kongsaktrakoon ¹, C Manamuti ¹, R Temsiririrkkul ¹

¹Faculty of pharmacy, Mahidol university, 447 Sri-Ayudhya, Rajthewi, Bangkok, 10400, Thailand

Congress Abstract

The aim of the present study was to develope the commercial mouthwash combined with herbal extracts against Streptococcus mutans ATCC 25175. The 50% ethanol herbal extracts were from Cassia alata L., Quercus infectoria Oliver., Harrisonia perforata Merr., Camellia sinensis L. (oolong and green tea) and Psidium guajava L.,

H. perforata and P. guajava exhibited the highest antibacterial activity of 0.625mg/ml. However C. alata, C. sinensis (oolong and green tea) and Qu. infectoria showed antibacterial activity of 1.25mg/ml. Evaluation of the combination effect of commercial mouthwash with herbal extracts by synergy test found that C. alata, C. sinensis (oolong and green tea) and Qu. infectoria increased antibacterial activity against S. mutans ATCC 25175 (FIC=0.5) while H. perforata and P. guajava were indifference (FIC=1.0). The amount of commercial mouthwash used to inhibit S. mutans ATCC 25175 growth was then reduced 16 fold when combined with C. alata, C. sinensis (oolong and green tea) and Qu. infectoria.

It is concluded that the combined formulation of commercial mouthwash with herbal extracts can lead to the better treatment of dental caries caused from S. mutans.