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DOI: 10.1055/s-2007-986873
Vismiaturucallone, a new Antimalarial tetracyclic triterpene from Vismia laurentii (Clusiaceae)
In the framework of our interest in antimalarial natural products from Clusiaceae family [1,2], the apolar extract of the stem bark of Vismia laurentii showed good antimalarial activity (IC50=4.6µg/ml). Thus, the isolation of its constituents led to the identification of a new tetracyclic triterpene, (20-ethylnortirucalla-7,24-dien-3-one) vismiaturucallone (1) (Fig.1) along with eight known compounds namely 3-geranyloxyemodin, vismiaquinone A (3), vismiaquinone B, bivismiaquinone, epifriedelinol, betulinic acid, tirucalla-7,24-dien-3-one, and stigmasta-7,22-dien-3-ol. Compounds (1) and (3) showed antiplasmodial activity against chloroquine-resistant W2 strain of Plasmodium falciparum with IC50 of 1.17µM and 1.42µM, respectively.
References: [1] Ngouela, S. et al. (2005) Nat Prod Res 19(7):685–8. [2] Ngouela, S. et al. (2006) Phytochemistry 67(3):302–6.