Planta Med 2007; 73 - P_085
DOI: 10.1055/s-2007-986867

A novel isoflavonoid from Millettia puguensis

MC Kapingu 1, ZH Mbwambo 1, MJ Moshi 1, JJ Magadula 1, P Cos 2, D Vanden Berghe 2, L Maes 3, M Theunis 2, S Apers 2, L Pieters 2, A Vlietinck 2
  • 1Institute of Traditional Medicine, Muhimbili University College of Health Sciences, P.O. Box 65001, Dar es Salaam, Tanzania
  • 2Departments of Pharmaceutical and
  • 3Biomedical Sciences, University of Antwerp, B-2610 Antwerp, Belgium

From the roots of Millettia puguensis (Leguminosae), a novel isoflavonoid (1), 2'-methoxy-4',5'-methylenedioxy-7,8-[2-(1-methylethenyl)furo]isoflavone, and four known compounds, i.e., lupeol, (-)-maackiain (2), 6,7-dimethoxy-3',4'-methylenedioxyisoflavone (3) and 7,2'-dimethoxy-4',5'-methylenedioxyisoflavone were isolated and identified by 1H-, 13C-NMR and mass spectroscopy. All compounds were evaluated for their antiprotozoal and cytotoxic activities, but only a moderate antileishmanial activity was observed for compound 3 (IC50 32µM against Leishmania infantum), and a moderate cytotoxicity for compound 2 (IC50 43µM on MRC-5 cells) [1].

1

2

3 R1=OMe, R2=H

References: 1. Kapingu et al. (2006) Planta Med. 72: 1341–1343