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PiD - Psychotherapie im Dialog 2007; 8(4): 342-346
DOI: 10.1055/s-2007-986271
Aus der Praxis

© Georg Thieme Verlag KG Stuttgart · New York

Neurobiologie und Borderline-Persönlichkeitsstörung

Sabine  C.  Herpertz
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Publication History

Publication Date:
27 November 2007 (online)

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Zusammenfassung

Dispositionell-genetische als auch psychosoziale Faktoren - besonders solche im Kontext früher Traumata - begründen die Kerndimension der Affektdysregulation bei der Borderline-Persönlichkeitsstörung, die wiederum eng verknüpft ist mit Impulsivität, Dissoziation und selbst- bzw. fremdschädigendem Verhalten. Die heutige Datenlage und hier besonders strukturelle sowie funktionelle bildgebende Befunde verweisen auf eine amygdalare Hyperreagibilität, wahrscheinlich im Konzert mit einer verminderten präfrontalen Top-down-Kontrolle. Einer serotonergen präfrontalen Dysfunktion kommt darüber hinaus für die Impulsivität eine wichtige Rolle zu und schließlich scheint das für das Verständnis des Selbstverletzungsverhaltens wichtige veränderte Schmerzerleben auch eine neurobiologische Grundlage zu haben.

Schlüsselwörter

Borderline-Persönlichkeitsstörung - Affektregulationsstörung - Impulsivität - präfronto-limbische Netzwerkstörung

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Korrespondenzadresse:

Prof. Dr. Sabine C. Herpertz

Klinik für Psychiatrie und Psychotherapie der Universität Rostock

Gehlsheimer Straße 20

18119 Rostock

Email: sabine.herpertz@med.uni-rostock.de

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