Abstract
Post-translational attachment of small ubiquitin-like modifier (SUMO), defined as
SUMOylation, can affect the localization, interactions, stability and/or activity
of substrate proteins, and thus can participate in a large variety of cellular processes.
Most SUMO substrates are involved in transcriptional regulation. Hence, SUMOylation
can either activate or, more commonly, repress gene transcription. The modulation
of gene expression by SUMO through diverse mechanisms and specifically the recent
findings concerning SUMOylation in pancreatic β-cells are reviewed.
Key words
insulin - diabetes - ICA512 - PDX-1 - Maf-A - STAT - PIAS
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Correspondence
M. Solimena
Experimental Diabetology
Carl Gustav Carus Medical School
Dresden University of Technology
Fetscherstrasse 74
01307 Dresden
Germany
Phone: +49/351/458 66 11
Fax: +49/351/458 63 30
Email: michele.solimena@tu-dresden.de