Double-balloon enteroscopy for the diagnosis and treatment of obscure bleeding, inflammatory bowel diseases and polyposis syndromes: we see more but do we know more?

Background/Aims: Our aim was to report our experience with the Fujinon EN-450 T5 therapeutic double-balloon endoscope (DBE) in the diagnosis of small bowel diseases. Methodology: Between August 2005 and October 2006, 52 DBE procedures were conducted in 47 consecutive patients (M/F: 22/25, age:51.6 SD19.5years) presenting at our tertiary referral hospital (37 and 7 patients from oral and anal route, respectively; 5 patients from both). All procedures were performed using i.v. anesthesia, at our outpatient clinic. Results: Indication included suspected small-bowel bleeding in 28 patients, suspected/known IBD in 12 and polyposis/suspected neoplasia in 7. In obscure bleeding small-bowel abnormality was found in 18 patients (64.3%) including angiodysplasias/erosions and one polypoid lesion. In suspected IBD, it was diagnosed in 2 out of 8 cases. In patients with polyposis syndromes, polyps were found in two Peutz-Jeghers patients, while another patient with suspected stenosis was diagnosed with primary adenocarcinoma. The average insertion length was app. 213cm. No severe complications were observed. Conclusions: Based on our experience DBE is a safe and useful method for evaluating and treating small bowel disease in selected patients with obscure bleeding, IBD or polyposis syndromes, however, the clinical importance of minute lesions still needs to be determined.