Securidaca longepedunculata Fres., der Wilde Veilchenbaum

Zusammenfassung

Securidaca longepedunculata ist ein Baum bzw. Strauch, der im tropischen Afrika beheimatet ist und dessen Wurzel in der afrikanischen Volksheilkunde breite Anwendung findet. Ethnomedizinische Untersuchungen haben eine Verwendung zur Behandlung von Schmerzen und Infektionskrankheiten und weitere interessante Einsatzgebiete aufgezeigt. Auffallend sind der hohe Gehalt an Methylsalicylat und Saponinen sowie das Vorkommen von Mutterkornalkaloiden. Das typische Inhaltsstoffspektrum und Ergebnisse von In-vitro- und In-vivo-Untersuchungen lassen einen rationalen Hintergrund für die Anwendungsmöglichkeiten dieser Arzneipflanze vermuten.

Summary

Securidaca longepedunculata is a blooming tree or rather shrub which is endemic in tropical Africa and whose root is widely used in traditional medicine. Ethnomedical examination revealed the use against pain and infectious diseases and showed further interesting applications. Remarkable are the high amounts of methylsalicylate and saponines in the root as well as the occurrence of ergot alkaloids. The typical spectrum of natural products, as well as in vitro and in vivo investigations, support a rational background for the application of this plant.

Schlüsselwörter

Securidaca longepedunculata Fres. - Polygalaceae - Ethnopharmakologie - Afrika - Arzneipflanze

Key words

Securidaca longepedunculata Fres. - Polygalaceae - ethnopharmacology - African medicinal plants

Literatur

• 1 Aderbauer B, Clausen PH, Melzig MF. Screening of medical plants from Mali for antitrypanosomal activity.  Planta Med. 2006;  72 992
• 2 Ajali U, Chukwurah BK. Antimicrobial activity of Securidaca longipedunculata.  Phytomedicine. 2004;  11 701-703
• 3 Ancolio C, Azas N, Mahiou V. et al. . Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome.  Phytother Res. 2002;  16 646-649
• 4 Atawodi SE, Bulus T, Ibrahim S. et al. . In vitro trypanocidal effect of methanolic extract of some Nigerian savannah plants.  Afr J Biotechnol. 2003;  2 317-321
• 5 Clark L, Shivik J. Aerosolized essential oils and individual natural product compounds as brown treesnake repellents.  Pest Manag Sci. 2002;  58 775-783
• 6 Costa C, Bertazzo A, Allegri G. et al. . Indole alkaloids from the roots of an African plant Securidaca longipedunculata. I: Isolation by column chromatography and preliminary structural characterization by mass spectrometry.  J Heterocycl Chem. 1992;  29 1641-1647
• 7 Tommasi N De, Piacente S, Simone F De. et al. . New sucrose derivatives from the bark of Securidaca longipedunculata.  J Nat Prod. 1993;  56 134-137
• 8 Delaude C. Les polygalaceae et leurs saponines (Polygalaceae saponins) (Polygalaceae and their saponins).  Bull Soc R Sci Liège. 1992;  61 245-288
• 9 Galeffi C, Federici E, Msonthi JD. et al. . New xanthones from Extiadiopis oblongifolia and Securidaca longepedunculata.  Fitoterapia. 1990;  61 79-80
• 10 Hamburger M, Gupta M, Hostettmann K. Flavonol glycosides from Securidaca diversifolia.  Phytochemistry. 1985;  24 2689-2692
• 11 Hyde M, Wursten B, Securidaca L. Description of the genus.  www.zimbabweflora.co.zw
• 12 Irvine FR. Woody Plants of Ghana. With Special Reference to their Uses. London: Oxford University Press 1961: 60-62
• 13 Jayasekara TK, Stevenson PC, Belmain SR. et al. . Identification of methyl salicylate as the principal volatile component in the methanol extract of root bark of Securidaca longepedunculata Fers.  J Mass Spectrom. 2002;  37 577-580
• 14 Jayasekara TK, Stevenson PC, Hall DR. et al. . Effect of volatile constituents from Securidaca longepedunculata on insect pests of stored grain.  J Chem Ecol. 2005;  31 303-313
• 15 Kogan VI, Gorbunov VD, Rostotskii BK. U.S.S.R. Patent No. 277. 1970;  796
• 16 Kone PP. Études toxicologiques, electrophysiologiques et pharmacologiques du venin de Naja nigrocollis et dŽune substance antivenineuse de la pharmacopée traditionnelle africaine (extrait de Securidaca longepedunculata) [Ph. D. Thesis]. Université Nationale de Côte d'Ivoire 1980
• 17 Kucht S, Gross J, Hussein Y. et al. . Elimination of ergoline alkaloids following treatment of Ipomoea asarifolia (Convolvulaceae) with fungicides.  Planta. 2004;  219 619-625
• 18 Mahmood N, Moore PS, Tommasi N De. et al. . Inhibition of HIV infection by caffeoylquinic acid derivatives.  Antivir Chem Chemother. 1993;  4 135-140
• 19 Mouzou AP, Bulteau L, Raymond G. The effects of Securidaca longepedunculata root extract on ionic currents and contraction of cultured rat skeletal muscle cells.  J Ethnopharmacol. 1999;  65 157-164
• 20 Neuwinger HD. Afrikanische Arzneipflanzen und Jagdgifte: Chemie, Pharmakologie, Toxikologie. 2. Aufl. Stuttgart: Wissenschaftliche Verlagsgesellschaft 1998: 758-768
• 21 Olajide OA, Ajayi FF, Ekhelar AI. et al. . Gastrointestinal tract effects of Securidaca longepedunculata root extract.  Pharmaceut Biol. 1999;  37 134-137
• 22 Olajide OA, Awe SO, Makinde JM. Pharmacological screening of the root extract of Securidaca longepedunculata.  Fitoterapia. 1998;  68 245-248
• 23 Petkov V, Georgiev V, Roussinov K. et al. . On the pharmacology of the ergot alkaloid elymoclavine.  Biomed Biochim Acta. 1984;  43 1305-1316
• 24 Prista LN, Correira AA. Estude farmacognostico da Securidaca longepedunculata.  Garcia de Orta. 1958;  6 131-147
• 25 Rakuambo NC, Meyer JJ, Hussein A. Xanthone isolated from Securidaca longependunculata with activity against erectile dysfunction.  Fitoterapia. 2004;  75 497-499
• 26 Scandola M, Games DE, Costa C. et al. . Structural study of alkaloids from Securidaca longipedunculata roots. II. Isolation and characterization by supercritical fluid chromatography/mass spectrometry.  J Heterocyclic Chem. 1994;  31 219-224
• 27 Tubery P, Demande F. Antiinflammatory triterpenic alcohol acids. FR Patent No. 2202683 1974
• 28 Umezu T. Saponins and surfactants increase water flux in fish gills.  Nippon Suisan Gakkai Shi. 1991;  57 1891-1896
• 29 Watt JM, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. Edinburgh & London: E. & S. Livingstone, Ltd 1962: 853-857
• 30 Wrobel JT, Matuszewska M, Szychowski J. et al. . Indole alkaloids and other constituents from the plant Securidaca longipedunculata Fres.  Adv Exp Med Biol. 1996;  398 685-689
• 31 Yang XD, An N, Xu LZ. et al. . New xanthone glycosides from Securidaca inappendiculata.  J Asian Nat Prod Res. 2002;  4 141-145
• 32 Zhang LJ, Yang XD, Xu LZ. et al. . A new sterol glycoside from Securidaca inappendiculata.  J Asian Nat Prod Res. 2005;  7 649-653