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Planta Med 2007; 73(12): 1281-1284
DOI: 10.1055/s-2007-981615
Pharmacology
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Protective Effect of Magnoflorine Isolated from Coptidis Rhizoma on Cu2+-Induced Oxidation of Human Low Density Lipoprotein

Tran Manh Hung1 , MinKyun Na1 , Byung Sun Min2 , Xinfeng Zhang3 , IkSoo Lee1 , Tran Minh Ngoc1 , Phuong Thien Thuong1 , Dai-Eun Sok1 , KiHwan Bae1
  • 1College of Pharmacy, Chungnam National University, Daejeon, Korea
  • 2College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea
  • 3School of Forestry and Bioscience Technology, ZheJiang Forestry University, Lin'an, ZheJiang, P. R. China
Further Information

Publication History

Received: March 31, 2007 Revised: June 29, 2007

Accepted: July 30, 2007

Publication Date:
20 September 2007 (online)

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Abstract

The aim of this study was to investigate the antioxidant activity of magnoflorine, an alkaloid isolated from Coptidis Rhizoma, against the oxidation of native low density lipoprotein (LDL) and modified LDL. Magnoflorine was found to inhibit the copper-mediated (Cu2+) oxidation of LDL, as well as of glycated and glycoxidated LDL by increasing the lag time of conjugated diene formation and preventing the generation of thiobarbituric acid reactive substances (TBARS). In addition, the results from the fluorescence emission spectra of tryptophan (Trp) supported that the antioxidant activity of magnoflorine could be associated with the protective effect on the structural modification of apolipoprotein B (apoB) required for LDL oxidation. These results suggest that magnoflorine may be useful for preventing the oxidation of various LDL forms.

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Prof. KiHwan Bae

College of Pharmacy

Chungnam National University

Daejeon 305-764

Korea

Phone: +82-42-821-5925

Fax: +82-42-823-6566

Email: baekh@cnu.ac.kr

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