Dendrazawaynes A and B, Antifungal Polyacetylenes from Dendranthema zawadskii (Asteraceae)

Abstract

Two new C₁₄ polyacetylenes dendrazawayne A (7) and dendrazawayne B (9) together with known C₁₃ polyacetylenes (2, 3), C₁₄ polyacetylenes (1, 4, and 8) and polyacetylene amides (5 and 6) were isolated from the roots of Dendranthema zawadskii. The structures of 7 and 9 were elucidated based on spectroscopic methods including 2D-NMR, HR-TOF-MS, IR, and UV. Compounds 1, 2, 3, 5, and 6 showed moderate activity against tumor cell lines (human small lung cancer cell line A549, melanoma SK-Mel-2, and mouse melanoma B16F1) with IC₅₀ values in the range of 7.4 - 30 μg/mL. Compounds 7 and 9, including other polyacetylenes, showed strong activity against the fungus Trichophyton (MIC: 5 - 10 μg/mL).

Key words

Antifungal - Dendranthema zawadskii - Asteraceae - dendrazawayne A - dendrazawayne B - cytotoxicity - polyacetylenes

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