Planta Med 2007; 73(10): 1112-1115
DOI: 10.1055/s-2007-981562
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Three Novel Sterols Isolated from Selaginella tamariscina with Antiproliferative Activity in Leukemia Cells

Liang-liang Gao1 , Shi-liang Yin2 , Zhan-lin Li1 , Yi Sha2 , Yue-hu Pei1 , Guang Shi2 , Yong-kui Jing3 , Hui-ming Hua1
  • 1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 2School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 3Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Further Information

Publication History

Received: January 6, 2007 Revised: May 30, 2007

Accepted: June 5, 2007

Publication Date:
05 July 2007 (online)

Abstract

Three new sterols, 3β,16α-dihydroxy-5α,17β-cholestan-21-carboxylic acid (1), 3β-acetoxy-16α-hydroxy-5α,17β-cholestan-21-carboxylic acid (2) and 3β-(3-hydroxybutyroxy)-16α-hydroxy-5α,17β-cholestan-21-carboxylic acid (3) were isolated from Selaginella tamariscina (Beauv.) Spring (Selaginellaceae). Their structures were elucidated based on NMR analyses. The growth inhibitory effects and differentiation induction abilities of compounds 1 - 3 were determined in human leukemia HL-60 cells. Compound 1 was more effective than compounds 2 and 3 in inhibiting cell growth, but compound 3 was more effective than compounds 1 and 2 in enhancing induction of all-trans-retinoic acid differentiation.

References

Prof. Dr. Hui-ming Hua

Shenyang Pharmaceutical University

Box 49

Shenyang 110016

People's Republic of China

Phone: +86-24-2398-6465

Fax: +86-24-2398-6465

Email: huimhua@163.com

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