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Horm Metab Res 1995; 27(5): 244-250
DOI: 10.1055/s-2007-979949
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

Parathyroid Hormone Secretion and Serum Calcium Concentration - A Deterministic View of its Regulation

E. Heidbreder1 , H. Naujoks1 , U. Brosa2 , L. Schramm1 , R. Götz1
  • 1Medizinische Universitätsklinik Wiürzburg
  • 2Brosa GmbH, Amöneburg, Germany
Further Information

Publication History

1994

1995

Publication Date:
23 April 2007 (online)

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Abstract

In seven normal men we investigated the basal secretion of PTH by blood sampling in 30 sec intervals for estimation of intact PIH and at 2-min intervals for measurement of ionized calcium. In 4 of these subjects we also investigated the PTH-secretion under conditions of intermittent hypercalcemia and hypocalcemia. Our measurements demonstrate the existence of three time scales in the secretion of PTH, viz, short-term pulses (faster than 2 min), an intermediate pattern of adjusting PTH levels to changed Ca2+ averages, and finally a long-term coupling between PTH and Ca2+ averages after 20 min. Ionized calcium controls the long-term regulation and intermediate adaptation mechanisms, but the short-term fluctuations seem to be due to spontaneous secretion.

Key words

Parathyroid Hormone Secretion - Hypocalcemia - Hypercalcemia - Deterministic Aspects

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