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DOI: 10.1055/s-2007-979941
© Georg Thieme Verlag Stuttgart · New York
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Publication History
1994
1994
Publication Date:
23 April 2007 (online)

Abstract
Some reports have suggested the ameliorative effects of estrogens on clinical symptoms, such as short memory, in women suffering from senile dementia-Alzheimer's tpye, in vivo. The action mechanism of estrogen remains to be clarified, but 1) an anti-depressive effect, 2) improvement of cerebral blood flow, 3) direct stimulation of neuron, 4) development of gliacyte and 5) suppression of apolipoprotein E have been suggested. Some mechanisms may be combined, contributing to the beneficial effects on clinical symptoms.
Key words
Senile Dementia-Alzheimer's Type - Estrogen - Depressive Status - Cerebral Blood Flow - Neuron - Apolipoprotein E