The Influence of Estrogens, Progesterone and their Antagonists on the Collagen Content in the Pregnant Rat Uterus

A. Bieńkiewicz; J. Welfel; Ewa Kuś

doi:10.1055/s-2007-979859

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Horm Metab Res 1996; 28(11): 592-594
DOI: 10.1055/s-2007-979859

Originals Clinical

The Influence of Estrogens, Progesterone and their Antagonists on the Collagen Content in the Pregnant Rat Uterus

A. Bieńkiewicz, J. Welfel, Ewa Kuś

Institute of Gynecology and Obstetrics, Department of Pathophysiology, Medical University of łódź, łódź, Poland

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Publication History

1995

1996

Publication Date:
23 April 2007 (online)

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Abstract

The influence of progesterone, estrogens and their antagonists: mifepristone and tamoxifen on connective tissue metabolism in pregnant rat uterus near term was evaluated. Total collagen and its soluble fraction as well as water concentration was measured in a population of 65 pregnant rats; treated with progesterone (n = 10), mifepristone (n = 13), estradiol (n = 17) and tamoxifen (n = 12). The results suggest the important influence of sex steroids on the uterine connective tissue metabolism during pregnancy.

Key words

Uterus - Collagen - Progesterone - Mifepristone - Estradiol - Tamoxifen