Cerebral Proton Magnetic Resonance Spectroscopy in Rett Syndrome

F. Hanefeld; H.-J. Christen; U. Holzbach; B. Kruse; J. Frahm; W. Hänicke

doi:10.1055/s-2007-979742

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Neuropediatrics 1995; 26(2): 126-127
DOI: 10.1055/s-2007-979742

Neurobiology and neuroimaging

Cerebral Proton Magnetic Resonance Spectroscopy in Rett Syndrome

F. Hanefeld¹ , H.-J. Christen¹ , U. Holzbach¹ , B. Kruse¹ , J. Frahm² , W. Hänicke²

¹Kinderklinik, Schwerpunkt Neuropädiatrie, Georg-August-Universität, Robert-Koch-Str. 40, Göttingen
²Biomedizinische NMR-Forschungs GmbH, Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany

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Publication History

Publication Date:
19 April 2007 (online)

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Abstract

Combined MRI/MRS studies were performed in 9 girls with Rett syndrome of different ages. NAA, as marker of neuronal tissue, was found to decrease with increasing age. There was no evidence for a defective energy metabolism. The data point towards a probably secondary degenerative process in the pathogenesis of Rett syndrome.

Key words

Rett syndrome - MR spectroscopy

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