Semin Liver Dis 2007; 27(2): 227-230
DOI: 10.1055/s-2007-979473

Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Fibrin Ring Granuloma in Chronic Hepatitis C: Virus-Related Vasculitis and/or Immune Complex Disease?

Emily Glazer1 , Asim Ejaz2 , Curtis James Coley1  II , Karl Bednarek1 , Neil D. Theise1 , 2
  • 1Department of Medicine, Division of Digestive Diseases, Beth Israel Medical Center, New York, New York
  • 2Department of Pathology, Beth Israel Medical Center, New York, New York
Further Information

Publication History

Publication Date:
22 May 2007 (online)


Fibrin ring granulomas are rare lesions whose pathophysiology has remained somewhat elusive. It has been suggested that these peculiar lesions are related to focal vasculitis with endothelial injury and deposition of immune complexes. Fibrin ring granulomas have been described in Q fever; in viral infections such as cytomegalovirus, Epstein-Barr virus, and hepatitis A virus; and in other conditions. We submit the first reported case of fibrin ring granuloma in a patient with chronic hepatitis C infection, in whom other potential etiologies have been excluded, and offer a brief review of available literature on the pathogenesis of both conditions.


Emily Glazer, M.D. 

Division of Digestive Diseases, Beth Israel Medical Center

First Avenue at 16th Street, New York, NY 10003