Endotoxin Modulates Arachidonic Acid-induced Glycogenolysis in the Perfused Rat Liver

K. Kimura; M. Moriyama; M. Nishisako; Y. Kannan; M. Shiota; T. Sugano

doi:10.1055/s-2007-978862

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Horm Metab Res 1998; 30(4): 178-181
DOI: 10.1055/s-2007-978862

Originals Basic

Endotoxin Modulates Arachidonic Acid-induced Glycogenolysis in the Perfused Rat Liver

K. Kimura¹ ^, ² , M. Moriyama² , M. Nishisako² , Y. Kannan² , M. Shiota² , T. Sugano²

¹Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
²Department of Veterinary Physiology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka, Japan

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Publication History

1997

1997

Publication Date:
20 April 2007 (online)

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Effects of endotoxin on arachidonic acid (AA)-induced hepatic glycogenolysis were examined in perfused rat liver. In normal rat liver, infusion of AA increased oxygen consumption and glucose production concurrently. In rats injected with lipopoly-saccharide (LPS) 6 h before, AA increased glucose production but suppressed oxygen consumption. The changes in LPS-injected rat were abolished by a thromboxane (Tx) A₂ receptor antagonist. The release of Tx B₂ by AA increased after LPS-injection. These results suggest that priming of hepatic macrophage by endotoxin in vivo enhances Tx synthesis, resulting in modulating hepatic glycogenolysis.

Key words

LPS (Lipopolysaccharide) - Prostaglandin - Thromboxane