A method is described for measuring the acute blood glucose response to an insulin
challenge which requires only 6 samples of 20 µl of blood collected over a 4 hour
period. This evaluation of sensitivity to insulin was validated by comparing the effects
of gliclazide, metformin and a novel antidiabetic imidazoline compound (S22068) on
the blood glucose response. The test distinguished between the insulin-secreting and
hypoglycaemic action of gliclazide and the insulin-sensitizing actions of metformin
and S22068. The test has the advantage that it can be repeated in the same animal
after a period of recovery and thus enables the overall sensitivity to insulin to
be compared before and after acute or chronic dose regimes.
Blood Glucose - Oral Hypoglycaemic Drugs
