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© Georg Thieme Verlag Stuttgart · New York
Effects of Bilateral Splanchnic-Nerve Section and Chemical Sympathectomy on PACAP38 Content in the Rat Adrenals
20 April 2007 (online)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a basic 38-amino acid regulatory peptide contained in the adrenal gland and involved in the control of its secretory activity. Bilateral splanchnic-nerve section caused in the rat a significant decrease in PACAP38 adrenal content and concentration, as measured by RIA. In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important role in the control of rat adrenal function.
PACAP - Adrenal Gland - Splanchnotomy - Sympathectomy - Rat