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Neuropediatrics 1996; 27(5): 273-276
DOI: 10.1055/s-2007-973778
Short communications

© Hippokrates Verlag GmbH Stuttgart

Lissencephaly with Extreme Cerebral and Cerebellar Hypoplasia. A Magnetic Resonance Imaging Study

A. A. Kroon2 , B. J. Smit1 , P. G. Barth2 , 3 , R. C. M. Hennekam2 , 4
  • 1Departments of Neonatology, Academic Medical Centre, Amsterdam, The Netherlands
  • 2Departments of Pediatrics, Academic Medical Centre, Amsterdam, The Netherlands
  • 3Departments of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
  • 4Institute for Human Genetics, Academic Medical Centre, Amsterdam, The Netherlands
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Publikationsdatum:
13. März 2007 (online)

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Abstract

A newborn with a rare type of lissencephaly is reported, characterized by extreme cerebral and cerebellar hypoplasia. The diagnosis was made by postmortem magnetic resonance imaging, indicating the value of such studies to evaluate neuronal migration disorders in patients in whom autopsy cannot be performed. Two earlier described microlissencephaly syndromes, the "Barth" and "McComb" type, are reviewed.

Key words

Cerebellar hypoplasia - Lissencephaly - Microcephaly - Microlissencephaly