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Neuropediatrics 1997; 28(1): 77-79
DOI: 10.1055/s-2007-973676
Short communications

© Hippokrates Verlag GmbH Stuttgart

Lamotrigine Therapy in Infantile Neuronal Ceroid Lipofuscinosis (INCL)

Laura Åberg1 , H. Heiskala2 , S.-L. Vanhanen1 , J. J. Himberg1 , G. Hosking3 , A. Yuen3 , P. Santavuori1
  • 1Children's Hospital, Pediatric Neurology, University of Helsinki,
  • 2Rinnekoti Foundation, Espoo
  • 3Glaxo Wellcome
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Publikationsdatum:
13. März 2007 (online)

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Abstract

Since 1990, altogether 16 INCL patients received lamotrigine (LTG) because of intractable epilepsy. The response to LTC was favorable in 15/16 children. The severity of seizures decreased significantly in 15/16 patients, the frequency of seizures decreased in 14/16, and the effects were maintained. In addition, LTC had a beneficial effect on the wellbeing of 14/16 children. LTC failed to maintain it's efficacy in monotherapy. No severe side effects were found.

Key words

Infantile neuronal ceroid lipofuscinosis - Lamotrigine - Epilepsy