Abstract
Some anti-allergic agents act as histamine H1 antagonists and induce seizure discharges in epileptic patients. Of these agents,
ketotifen has an especially potent effect. We have experienced 2 cases of 4-month-old
boys who developed infantile spasms 8 to 10 days after ketotifen administration. They
showed almost the same clinical course with regard to their age, the interval between
ketotifen administration and the onset of seizures, their symptoms and EEG abnormalities.
These cases suggest that the administration of ketotifen to young infants may be hazardous
with regard to inducing infantile spasms.
Key words
Infantile spasms - Histamine H1 antagonist - Ketotifen - Seizure - Infant
