Effects of Cannabis sativa Extract on Testicular Function of Presbytis entellus entellus

Abstract

Chronic administration of cannabis extract (14 mg/kg body wt for 90 days) caused testicular lesions resulting in mass atrophy of the spermatogenic elements. RNA, protein and sialic acid contents of the testes and epididy-mides were reduced; whereas the alkaline phosphatase and cholesterol contents of the testes were elevated. Liver glycogen and adrenal ascorbic acid contents were low. Degranulation and vacuolization of hepatocytoplasm was conspicuous which was further reflected in elevated transaminases, bilirubin, NEFA, phospholipids, free and total cholesterol. Serum protein, alkaline and acid phosphatase, triglycerides, blood sugar, blood urea and creatinine phosphate levels were in normal range. Hematological studies did not reveal any deviation from the normal range except a rise in leucocyte counts.

In conclusion, the severity and consistency of damage caused to the testis and liver in man by frequent use of marijuana and its derivatives is very alarming.

Key Word Index

Cannabis sativa - Cannabaceae - Testicular Function - Transaminases