Abstract
Inhibition of the uptake of 3H-thymidine into TLX-5 mouse lymphoma cells has been used to assess the cytotoxicity
of extracts and fractions of Brucea javanica. Six bruceolides, two dehydrobruceolides and a dihydrobruceolide have been isolated
from roots, fruits and stems. Bruceine A was the major bruceolide of the roots and
of the fruits. The potent antineoplastic bruceolides, bruceantin and bruceantinol,
previously isolated from B. antidysenterica and B. guineensis have been isolated together with the novel compounds dehydrobruceine A and dihydrobruceine
A. Bruceantarin and dehydrobruceine B, not previously reported from this species,
and bruceines B and C were also isolated. The identification of these nine compounds
by means of their UV, EIMS, CIMS, FDMS and 1H NMR spectra is discussed.
Key Word Index
Brucea javanica - Simaroubaceae - Bruceolides - NMR and MS - TLX-5 Mouse Lymphoma
- Anti-Cancer
