Quaternary Indole Alkaloids of Strychnos decussata

A. A. Olaniyi; W. N. A. Rolfsen; R. Verpoorte

doi:10.1055/s-2007-971523

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Planta Med 1981; 43(12): 353-359
DOI: 10.1055/s-2007-971523

Research Articles

Quaternary Indole Alkaloids of Strychnos decussata

A. A. Olaniyi¹ , W. N. A. Rolfsen² , R. Verpoorte³

¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ife, Ile-Ife, Nigeria
²Department of Pharmacognosy, Faculty of Pharmacy, Biomedical Centre, University of Uppsala, Uppsala, Sweden
³Department of Pharmacognosy, Gorlaeus Laboratories, University of Leiden, RA Leiden, The Netherlands

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Publication History

Publication Date:
30 March 2007 (online)

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Abstract

A new muscle-relaxant alkaloid named malindine has been isolated from the stem bark of Strychnos decussata, along with the previously known alkaloids macusine B, O-methylmacusine B and an alkaloid of macusine A or C-type.

The structure of malindine is proposed on the basis of spectral data and its pharmacological activity is discussed.

Key Word Index

Strychnos decussata - Loganiaceae - Macusine B - O-methylmacusine B - Malindine - Quaternary indole alkaloids - Muscle-relaxation