23 individual flavonoids and 23 flavonoid mixtures were assayed for their inhibition of the high Km cyclic AMP phosphodiesterase (PDE) in rat heart. Some of the flavonoids showed I50 in the micromolar range whereas others were less potent. The enzyme inhibition was of noncompetitive type. Some of the flavonoid mixtures showed an inhibitory activity comparable to that of the most potent individual compounds.
Flavonoids - Flavonoid Mixtures - cAMP Phosphodiesterase Inhibitors
