Planta Med 1981; 43(10): 183-186
DOI: 10.1055/s-2007-971497
Research Articles

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Inhibitory Effect of Some Flavonoids and Flavonoid Mixtures on Cyclic AMP Phosphodiesterase Activity of Rat Heart

E. Petkov, N. Nikolov, P. Uzunov
  • Department of Pharmacology and Phytotherapy, Medical Academy, Sofia, Bulgaria
Further Information

Publication History

Publication Date:
30 March 2007 (online)


23 individual flavonoids and 23 flavonoid mixtures were assayed for their inhibition of the high Km cyclic AMP phosphodiesterase (PDE) in rat heart. Some of the flavonoids showed I50 in the micromolar range whereas others were less potent. The enzyme inhibition was of noncompetitive type. Some of the flavonoid mixtures showed an inhibitory activity comparable to that of the most potent individual compounds.