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Planta Med 1982; 45(7): 183-187
DOI: 10.1055/s-2007-971370
Research Articles

© Hippokrates Verlag Stuttgart

Effects of Various Coumarins from Roots of Angelica dahurica on Actions of Adrenaline, ACTH and Insulin in Fat Cells

Yoshiyuki Kimura1 , Hiroji Ohminami1 , Hideko Arichi1 , Hiromichi Okuda1 , Kimiye Baba2 , Mitsugi Kozawa2 , Shigeru Arichi3
  • 12nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan
  • 2Osaka College of Pharmacy, Kawai-cho, Matsubara-City, Osaka 580, Japan
  • 3Research Institute of Oriental Medicine, Kinki University, Sayama-cho, Minamikawachi-gun, Osaka 589, Japan
Further Information

Publication History

1981

Publication Date:
29 March 2007 (online)

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Abstract

Experiments were carried out on the effects of various coumarins on the actions of adrenaline, adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats. Furocoumarins such as oxypeucedanin hydrate, bergapten, xanthotoxin, imperatorin, phellopterin activated adrenaline-induced lipolysis. Furocoumarins such as oxypeucedanin hydrate, imperatorin and phellopterin also activated ACTH-induced lipolysis. On the other hand, furocoumarins such as byak-angelicin, neobyakangelicol and isopimpinellin strongly inhibited insulin-stimulated lipogenesis. Therefore, the crude drug “Byakushi” may activate the actions of lipolytic hormones and selectively inhibit the effects of anti-lipolytic hormones.

Key Word Index

Angelica dahurica - Apiaceae (Umbelliferae) - Coumarins - Adrenaline-induced lipolysis - ACTH-induced lipolysis - Insulin-stimulated lipogenesis - Fat cells

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