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Semin intervent Radiol 2007; 24(1): 043-046
DOI: 10.1055/s-2007-971190
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

A Case of Pancreatic Islet Cell Transplantation in a Patient with Situs Ambiguous: Anatomical and Radiological Considerations

Rajesh P. Shah1 , James T. Bui1 , 2 , Derek L. West1 , 2 , Jose Oberholzer3 , Betul A. Hatipoglu4 , Joan N. Martellotto3 , Charles A. Owens1 , 2
  • 1Department of Radiology, University of Illinois Medical Center at Chicago, Chicago, Illinois
  • 2Section of Interventional Radiology, University of Illinois Medical Center at Chicago, Chicago, Illinois
  • 3Division of Transplant Surgery, University of Illinois Medical Center at Chicago, Chicago, Illinois
  • 4Department of Endocrinology, University of Illinois Medical Center at Chicago, Chicago, Illinois
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Publication Date:
27 March 2007 (online)

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ABSTRACT

Pancreatic islet cell transplantation is an evolving treatment of severe, refractory type 1 diabetes that has been gaining more use, particularly after one year rates of insulin independence post-transplantation were found to approach 80% under the Edmonton protocol. Islet cell transplantation involves percutaneous delivery of harvested allogeneic β cells into the portal venous circulation for implantation into the liver. We present the case of a 35-year-old woman with type 1 diabetes and situs ambiguous with left isomerism and resultant variant anatomy of her portal venous anatomy who underwent islet cell transplantation, which, to our knowledge, has not been previously reported.

KEYWORDS

Pancreatic islet cell transplantation - situs ambiguous - treatment of diabetes mellitus

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Rajesh ShahM.D. 

Department of Radiology, University of Illinois Medical Center at Chicago

1740 West Taylor Street, MC 931, Chicago, IL 60612

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