Exp Clin Endocrinol Diabetes 2007; 115(4): 229-231
DOI: 10.1055/s-2007-970575

© J. A. Barth Verlag in Georg Thieme Verlag KG · Stuttgart · New York

Betacellulin variants and type 2 diabetes in the Old Order Amish

K. D. Silver 1 , X. Shi 1 , B. D. Mitchell 1
  • 1University of Maryland School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Nutrition
Further Information

Publication History

received 23. 8. 2006 first decision 19. 10. 2006

accepted 19. 10. 2006

Publication Date:
03 May 2007 (online)


Betacellulin is a member of the epidermal growth factor (EGF) family and may play a role in islet neogenesis and regeneration. To evaluate whether polymorphisms in this gene are associated with type 2 diabetes (T2DM) and impaired glucose tolerance (IGT), we genotyped 7 previously identified betacellulin variants in Amish subjects with T2DM (n=150), IGT (n=148) and normal glucose tolerance (NGT) (n=361). There were no significant differences in the allele frequencies of the variants among the 3 groups. In an expanded set of 729 nondiabetic Amish subjects, there was no significant association between the betacellulin variants and levels of glucose or insulin either fasting or during a 3 h oral glucose tolerance test, HOMA or insulin secretion index. These results are consistent with previous studies in Caucasian populations and suggest that variants in the betacellulin gene do not play a major role in the development of T2DM in Caucasian populations.



K. D. Silver

University of Maryland School of Medicine

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