Inhibition of Cyclic AMP Phosphodiesterase by Flavonoids

T. Nikaido; T. Ohmoto; U. Sankawa; T. Hamanaka; K. Totsuka

doi:10.1055/s-2007-970043

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Planta Med 1982; 46(11): 162-166
DOI: 10.1055/s-2007-970043

Research Articles

Inhibition of Cyclic AMP Phosphodiesterase by Flavonoids[1]

T. Nikaido² , T. Ohmoto² , U. Sankawa³ , T. Hamanaka⁴ , K. Totsuka⁴

²Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
³Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
⁴Ome Research Laboratory, Tobishi Pharmaceutical Co. Ltd., Ome, Tokyo, Japan

Further Information

Publication History

1982

Publication Date:
29 March 2007 (online)

Abstract
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Abstract

Nobiletin and irigenin were identified as inhibitors of cyclic AMP phosphodiesterase, which were contained in peels of immature fruits of Citrus reticulata BLANCO (Japanese name “Seihi”) and in rhizomes of Iris florentina L. The structure activity relationships of 33 flavonoids were studied and polymethoxy flavonoids were generally more inhibitory against cAMP phosphodiesterase than corresponding polyhydroxy flavonoids. Nobiletin, irigenin and pentamethyl quercetin showed inhibitory effect on barium sulphate transport in the small intestine of mice. Further pharmacological investigations have revealed that these flavonoids have cholinergic activity.

Key Word Index

Citrus reticulata - Iris florentina - Flavonoids - Isoflavonoids - Flavones - cAMP Phosphodiesterase - Inhibitors

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