Antispasmodic Effect of Hagenia abyssinica

M. Arragie; J. Metzner; H. Bekemeier

doi:10.1055/s-2007-969997

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Planta Med 1983; 47(4): 240-241
DOI: 10.1055/s-2007-969997

Research Articles

Antispasmodic Effect of Hagenia abyssinica

M. Arragie¹ , J. Metzner² , H. Bekemeier²

¹Department of Pharmacology, Medical Faculty, Addis Ababa University, Ethiopia
²Section of Pharmacy, Martin Luther University Halle-Wittenberg, German Democratic Republic

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Publication History

1982

1982

Publication Date:
26 March 2007 (online)

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Abstract

The water extract of Kosso, (Hagenia abyssinica, GMELIN) as used in traditional Ethiopian medicine, was tested on the isolated guinea pig ileum employing acetylcholine, histamine and barium chloride as spasmogens. The effect of all three spasmogens was antagonized by Kosso in a concentration range of 0.05-0.2 ml/10 ml of bathing fluid.

The mechanism of antagonism was non-competitive. This smooth muscle inhibitory effect might contribute to the taenicidal action of Kosso.

Key Word Index

Hagenia abyssinica - Rosaceae - Antispasmodic activity - Guinea pig ileum