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Planta Med 1983; 47(4): 237-239
DOI: 10.1055/s-2007-969996
DOI: 10.1055/s-2007-969996
Research Articles
© Hippokrates Verlag Stuttgart
Inhibition of Rat Heart Phosphodiesterase by some Rotenoids and Isoflavonoids
Further Information
Publication History
1982
1982
Publication Date:
26 March 2007 (online)
Abstract
Series of natural and semisynthetic rotenoids and isoflavonoids were studied for their inhibitory activity on cyclic AMP phosphodiesterase (PDE) in rat heart. Some of the compounds showed higher inhibitory activity than that of the most potent flavonoids. The chemical transformation of the starting natural compounds failed to increase their inhibitory potency. PDE inhibition was of a noncompetitive type.
Key Word Index
Rotenoids - Isoflavonoids - cAMP phosphodiesterase inhibitors