Inhibition of Rat Heart Phosphodiesterase by some Rotenoids and Isoflavonoids

E. Petkov; P. Uzunov; I. Kostova; T. Somleva; I. Ognyanov

doi:10.1055/s-2007-969996

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Planta Med 1983; 47(4): 237-239
DOI: 10.1055/s-2007-969996

Research Articles

Inhibition of Rat Heart Phosphodiesterase by some Rotenoids and Isoflavonoids

E. Petkov¹ , P. Uzunov¹ , I. Kostova² , T. Somleva² , I. Ognyanov²

¹Department of Pharmacology and Phytotherapy, Medical Academy, Sofia, Bulgaria
²Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria

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Publication History

1982

1982

Publication Date:
26 March 2007 (online)

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Abstract

Series of natural and semisynthetic rotenoids and isoflavonoids were studied for their inhibitory activity on cyclic AMP phosphodiesterase (PDE) in rat heart. Some of the compounds showed higher inhibitory activity than that of the most potent flavonoids. The chemical transformation of the starting natural compounds failed to increase their inhibitory potency. PDE inhibition was of a noncompetitive type.

Key Word Index

Rotenoids - Isoflavonoids - cAMP phosphodiesterase inhibitors