Cultivation of Tripterygium wilfordii Tissue Cultures for the Production of the Cytotoxic Diterpene Tripdiolide

J. P. Kutney; L. S. L. Choi; R. Duffin; G. Hewitt; N. Kawamura; T. Kurihara; P. Salisbury; R. Sindelar; K. L. Stuart; P. M. Townsley; W. T. Chalmers; F. Webster; G. G. Jacoli

doi:10.1055/s-2007-969913

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Planta Med 1983; 48(7): 158-163
DOI: 10.1055/s-2007-969913

Research Articles

Cultivation of Tripterygium wilfordii Tissue Cultures for the Production of the Cytotoxic Diterpene Tripdiolide

J. P. Kutney¹ , L. S. L. Choi¹ , R. Duffin¹ , G. Hewitt¹ , N. Kawamura¹ , T. Kurihara¹ , P. Salisbury¹ , R. Sindelar¹ , K. L. Stuart¹ , P. M. Townsley² , W. T. Chalmers² , F. Webster² , G. G. Jacoli³

¹Department of Chemistry, University of British Columbia, Vancouver, Canada
²Department of Food Science, University of British Columbia, Vancouver, Canada
³Agriculture Canada, Vancouver, Canada

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Publication History

1982

1983

Publication Date:
26 March 2007 (online)

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Abstract

The production of the cytotoxic agent tripdiolide employing plant tissue cultures of Tripterygium wilfordii is demonstrated. Detailed investigations of a developed cell line of T. wilfordii in terms of tripdiolide production versus variations in growth conditions, for example media composition, are presented. Also the age and size of the inoculum and the incubation period with respect to tripdiolide formation are evaluated.

Key Word Index

Tripterygium wilfordii - Celastraceae - Tissue culture - Tripdiolide production