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Planta Med 1983; 48(6): 111-115
DOI: 10.1055/s-2007-969901
Research Articles

© Hippokrates Verlag Stuttgart

Inhibition of Acetylcholinesterase Activity by some Isoquinoline Alkaloids*,**

J. Ulrichová1 , D. Walterová1 , V. Preininger1 , J. Slavík2 , J. Lenfeld3 , M. Cushman4 , V. Šimánek1
  • 1Institute of Medical Chemistry, Medical Faculty, Palacký University, Olomouc, ČSSR
  • 2Institute of Medical Chemistry and Biochemistry, Medical Faculty, J. Ev. Purkyně University, Brno, ČSSR
  • 3Institute of Pharmacology, Medical Faculty, Palacký University, Olomouc, ČSSR
  • 4Department of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, U.S.A.
* Part LXXXVI in the series: Isolation, Chemistry and Biology of Alkaloids from Plants of the Papaveraceae. For Part LXXXVII see: V. Preininger, Planta med. 45, 120 (1982)** Dedicated to the 75th Birthday of Professor Ulrich Weiss, Bethesda.
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Publication History

1982

1982

Publication Date:
26 March 2007 (online)

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Abstract

The effects of quaternary protoberberine and benzophenanthridine alkaloids on acetylcholinesterase (ACHE, EC 3.1.1.7) activity in vitro and on isolated rat duodenum and guinea pig ileum tissue preparations have been studied. The ACHE inhibitory activity of quaternary alkaloids depends on the cationpseudobase equilibrium of the studied alkaloids in solution. The relationship between pKR+ values and the biological activity is described. The influence of surfactants on pseudobase formation of benzo-phenanthridine alkaloids has been discussed.

Key Word Index

Protoberberine - Benzophenanthridine Alkaloids - Surfactants - Cation-Pseudobase Equilibrium - Acetylcholinesterase Activity - Cholinergic Agonist Action