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DOI: 10.1055/s-2007-969901
© Hippokrates Verlag Stuttgart
Inhibition of Acetylcholinesterase Activity by some Isoquinoline Alkaloids*,**
* Part LXXXVI in the series: Isolation, Chemistry and Biology of Alkaloids from Plants of the Papaveraceae. For Part LXXXVII see: V. Preininger, Planta med. 45, 120 (1982)** Dedicated to the 75th Birthday of Professor Ulrich Weiss, Bethesda.Publication History
1982
1982
Publication Date:
26 March 2007 (online)
Abstract
The effects of quaternary protoberberine and benzophenanthridine alkaloids on acetylcholinesterase (ACHE, EC 3.1.1.7) activity in vitro and on isolated rat duodenum and guinea pig ileum tissue preparations have been studied. The ACHE inhibitory activity of quaternary alkaloids depends on the cationpseudobase equilibrium of the studied alkaloids in solution. The relationship between pKR+ values and the biological activity is described. The influence of surfactants on pseudobase formation of benzo-phenanthridine alkaloids has been discussed.
Key Word Index
Protoberberine - Benzophenanthridine Alkaloids - Surfactants - Cation-Pseudobase Equilibrium - Acetylcholinesterase Activity - Cholinergic Agonist Action