Planta Med 1983; 48(5): 17-19
DOI: 10.1055/s-2007-969870
Research Articles

© Hippokrates Verlag Stuttgart

Biotransformation of Cannabidiol to Cannabielsoin by Suspension Cultures of Cannabis sativa and Saccharum officinarum

S. C. Hartsel1 , W. H.-T. Loh1 , L. W. Robertson2
  • 1Department of Microbiology, The Ohio State University, Columbus, Ohio, U.S.A.
  • 2College of Pharmacy, The Ohio State University, Columbus, Ohio, U.S.A.
Further Information

Publication History



Publication Date:
26 March 2007 (online)


Suspension cultures of Cannabis sativa L. and Saccharum officinarum L. have been shown to biotransform cannabidiol to Cannabielsoin under normal growth conditions. Both Cannabielsoin C-1 stereoisomers were produced. Mass spectral and chromatographic evidence were used in this identification. This is the first reported biologically catalyzed synthesis of Cannabielsoin as well as the first biotransformation of any cannabinoid by plant tissue culture systems. Possible mechanisms and significance of this conversion are discussed.