Biotransformation of Cannabidiol to Cannabielsoin by Suspension Cultures of Cannabis sativa and Saccharum officinarum

S. C. Hartsel; W. H.-T. Loh; L. W. Robertson

doi:10.1055/s-2007-969870

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Planta Med 1983; 48(5): 17-19
DOI: 10.1055/s-2007-969870

Research Articles

Biotransformation of Cannabidiol to Cannabielsoin by Suspension Cultures of Cannabis sativa and Saccharum officinarum

S. C. Hartsel¹ , W. H.-T. Loh¹ , L. W. Robertson²

¹Department of Microbiology, The Ohio State University, Columbus, Ohio, U.S.A.
²College of Pharmacy, The Ohio State University, Columbus, Ohio, U.S.A.

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Publication History

1982

1982

Publication Date:
26 March 2007 (online)

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Abstract

Suspension cultures of Cannabis sativa L. and Saccharum officinarum L. have been shown to biotransform cannabidiol to Cannabielsoin under normal growth conditions. Both Cannabielsoin C-1 stereoisomers were produced. Mass spectral and chromatographic evidence were used in this identification. This is the first reported biologically catalyzed synthesis of Cannabielsoin as well as the first biotransformation of any cannabinoid by plant tissue culture systems. Possible mechanisms and significance of this conversion are discussed.

Key Word Index

Cannabis sativa - Saccharum officinarum - Cannabidiol - Cannabielsoin - Tissue culture - Suspension culture - Biotransformation