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Planta Med 1983; 49(12): 240-243
DOI: 10.1055/s-2007-969859
Research Articles

© Hippokrates Verlag Stuttgart

New 6-Aryl-2-pyrones from Gentiana pedicellata*

Sh. Ghosal, A. A. K. Singh, K. Biswas
  • Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Banaras Hindu University, Varanasi, India
* Part 30 in the series: “Chemical Constituents of Gentianaceae”. For Part 29 see ref. [1].
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Publication History

1982

1983

Publication Date:
26 March 2007 (online)

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Abstract

Three new 6-aryl-2-pyrones, viz. pedicellin (1), pedicellanin (2), and pedicellatin (3), have been isolated from the whole plant of Gentiana pedicellata WALL., collected when in flower. The compounds have been characterized on the basis of chemical transformation and comprehensive spectral evidence. This is the first report of occurrence of 6-aryl-2-pyrones in a member of the family Gentianaceae. The other secondary metabolites, e.g. triterpene, secoiridoid, and degraded carotenoid, present in this species are typical of the Gentiana. 1 and 2 produced significant adaptogenic and anti-stress effects in animal models thereby justifying the use of the title species in popular medicine.

Key Word Index

Gentiana pedicellata - 6-aryl-2-pyrones - Pedicellin - Pedicellanin - Pedicellatin - Swertiamarin - (-)-loliolide - Ursolic acid - Adaptogenic effect