Planta Med 1983; 49(11): 185-187
DOI: 10.1055/s-2007-969845
Research Articles

© Hippokrates Verlag Stuttgart

Antihepatotoxic Principles of Curcuma longa Rhizomes[1]

Yoshinobu Kiso, Yuriko Suzuki, Noriko Watanabe, Yoshiteru Oshima, Hiroshi Hikino
  • Pharmaceutical Institute, Tohoku University, Sendai, Japan
Further Information

Publication History

10 10 1982

5 7 1983

Publication Date:
26 March 2007 (online)


An extract of the crude drug “ukon”, the rhizomes of Curcuma longa, exhibited intense preventive activity against carbon tetrachloride-induced liver injury in vivo and in vitro. The extract was subjected to fractionation by monitoring the activity by the in vitro assay methods employing carbon tetrachloride- and galactosamine-produced cytotoxicity in primary cultured rat hepatocytes. Curcuminoids were shown to possess significant antihepatotoxic action. The liver protective effects of some analogues of ferulic acid and p-coumaric acid, probable metabolites of the curcuminoids, were also evaluated.

1 Part 8 in Liver-protective drugs. This paper also constitutes Part 53 in the series on the validity of the Oriental medicines.