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© Hippokrates Verlag Stuttgart
Antihepatotoxic Principles of Curcuma longa Rhizomes
26 March 2007 (online)
An extract of the crude drug “ukon”, the rhizomes of Curcuma longa, exhibited intense preventive activity against carbon tetrachloride-induced liver injury in vivo and in vitro. The extract was subjected to fractionation by monitoring the activity by the in vitro assay methods employing carbon tetrachloride- and galactosamine-produced cytotoxicity in primary cultured rat hepatocytes. Curcuminoids were shown to possess significant antihepatotoxic action. The liver protective effects of some analogues of ferulic acid and p-coumaric acid, probable metabolites of the curcuminoids, were also evaluated.
Key Word Index
Curcuma longa - Zingiberaceae - Curcuminoids - Caffeic acid - Carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes - Antihepatotoxic activity