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Planta Med 1983; 49(11): 158-161
DOI: 10.1055/s-2007-969838
DOI: 10.1055/s-2007-969838
Research Articles
© Hippokrates Verlag Stuttgart
Etude complémentaire de la cytotoxicité de la mélinonine F, alcaloïde dérivé de la β-carboline
Complementary Study of Cytotoxic Activity of Melinonine FFurther Information
Publication History
1983
1983
Publication Date:
26 March 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/198311/lookinside/thumbnails/10.1055-s-2007-969838-1.jpg)
Abstract
The cellular effects of melinonine F, an alkaloid isolated from Strychnos melinoniana (South America) and Strychnos usambarensis (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA in vitro.
Key Word Index
Strychnos species - Loganiaceae - Indole alkaloids - Melinonine F - Cytotoxic agents - Cancer cells - DNA - Intercalation