Planta Med 1983; 49(11): 158-161
DOI: 10.1055/s-2007-969838
Research Articles

© Hippokrates Verlag Stuttgart

Etude complémentaire de la cytotoxicité de la mélinonine F, alcaloïde dérivé de la β-carboline

Complementary Study of Cytotoxic Activity of Melinonine FR. Bassleer1 , J.-M. Marnette1 , Ph. Wiliquet1 , M.-Cl. De Pauw-Gillet1 , M. Caprasse2 , L. Angenot2
  • 1Service d'Histologie et Cytologie, Faculté de Médecine, Université de Liège, Belgique
  • 2Laboratoire de Pharmacognosie, Institut de Pharmacie, Université de Liège, Belgique
Further Information

Publication History



Publication Date:
26 March 2007 (online)


The cellular effects of melinonine F, an alkaloid isolated from Strychnos melinoniana (South America) and Strychnos usambarensis (Central Africa), are analysed in cancer or normal cells in culture. A cytotoxic action is noted in both types of cells, at least for relatively high concentrations. These effects are probably due to interaction of the drug with chromatin. Physico-chemical analysis demonstrates partial intercalation of melinonine F on pure DNA in vitro.