© Hippokrates Verlag Stuttgart
The Action of Valepotriates on the Synthesis of DNA and Proteins of Cultured Hepatoma Cells
26 March 2007 (online)
Valtrate, didrovaltrate and deoxido-didrovaltrate were compared for toxicity on cultured rat hepatoma cells (HTC strain) and for their effects on the synthesis of DNA and proteins.
Despite lacking the epoxide function in C8-C11 position in its molecular structure, deoxido-didrovaltrate has a similar cytotoxicity to didrovaltrate. The toxicity of both these drugs is two times lower than that of valtrate.
Incorporation tests with 3H-thymidine and 3H-leucine on cultured HTC cells revealed that a low dose of valtrate, rapidly and extensively inhibits the synthesis of both DNA and proteins.
Didrovaltrate and deoxido-didrovaltrate have the same effect, but at double the dose.
Key Word Index
Valeriana wallichii - Valerianaceae - Valepotriates - Hepatoma cells - Cytotoxicity - DNA and protein synthesis