Planta Med 1983; 49(11): 138-142
DOI: 10.1055/s-2007-969834
Research Articles

© Hippokrates Verlag Stuttgart

The Action of Valepotriates on the Synthesis of DNA and Proteins of Cultured Hepatoma Cells

C. Bounthanh1 , L. Richert2 , J. P. Beck2 , M. Haag-Berrurier1 , R. Anton1
  • 1Laboratoire de Pharmacognosie, Université Louis Pasteur, Strasbourg, France
  • 2Institut de Physiologie générale, Université Louis Pasteur, Strasbourg, France
Further Information

Publication History



Publication Date:
26 March 2007 (online)


Valtrate, didrovaltrate and deoxido-didrovaltrate were compared for toxicity on cultured rat hepatoma cells (HTC strain) and for their effects on the synthesis of DNA and proteins.

Despite lacking the epoxide function in C8-C11 position in its molecular structure, deoxido-didrovaltrate has a similar cytotoxicity to didrovaltrate. The toxicity of both these drugs is two times lower than that of valtrate.

Incorporation tests with 3H-thymidine and 3H-leucine on cultured HTC cells revealed that a low dose of valtrate, rapidly and extensively inhibits the synthesis of both DNA and proteins.

Didrovaltrate and deoxido-didrovaltrate have the same effect, but at double the dose.