Planta Med 1983; 49(10): 99-102
DOI: 10.1055/s-2007-969824
Research Articles

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Cardiovascular and Neuromuscular Actions of Scopoletin from Fruit of Tetrapleura tetraptera

J. A. O. Ojewole1 , S. K. Adesina2
  • 1Department of Pharmacology, Faculty of Pharmacy, University of Ife, Ile-Ife, Nigeria
  • 2Drug Research and Production Unit, Faculty of Pharmacy, University of Ife, lle-lfe, Nigeria
Further Information

Publication History

1981

1983

Publication Date:
26 March 2007 (online)

Abstract

The cardiovascular and neuromuscular actions of scopoletin have been investigated in some laboratory animals. Pharmacological examination showed that it possessed depressor (hypotensive) effects in anaesthetized rats, produced negative chronotropic and inotropic responses on guinea-pig isolated atria, inhibited acetylcholine-induced contractures of the toad rectus abdominis muscle, and depressed or abolished electrically-evoked twitches of the chick isolated biventer-cervicis muscle or rat isolated phrenic-nerve hemidiaphragm muscle preparations. The pharmacological actions of scopoletin on the various organsystems examined were resistant to the actions of specific antagonists such as atropine and physostigmine. The pharmacological implications of these findings and plausible mechanism(s) of action of scopoletin are discussed.