Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul

Yamini B. Tripathi; O. P. Malhotra; S. N. Tripathi

doi:10.1055/s-2007-969626

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Planta Med 1984; 50(1): 78-80
DOI: 10.1055/s-2007-969626

Research Articles

Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul

Yamini B. Tripathi¹ , O. P. Malhotra¹ , S. N. Tripathi²

¹Department of Kayachikitsa, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India
²Biochemistry Section, Dept. of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India

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Publication Date:
26 February 2007 (online)

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Abstract

A ketosteroid has been isolated from the oleo-resin of Commiphora mukul and its structure (4,17(20)trans pregnandiene 3,16-dione; Z-guggulsterone) established from its physico-chemical properties, specially UV, IR, NMR and mass-spectra. The isolated ketosteroid showed a strong thyroid stimulatory action when administered to albino rats. Its administration (1 mg/100 g body weight) brought about an increase in iodine-uptake by thyroid and enhanced activities of thyroid peroxidase and protease as well as oxygen consumption by isolated slices of liver and biceps muscle.