Ein Oxepan-Derivat des Panaxadiols aus den Blättern von Panax notoginseng

Wei Junxiang; Chang Liangyu; Wang Jufen; Chen Wei-shin; Edmund Friedrichs; Heinrich Puff; Eberhard Breitmaier

doi:10.1055/s-2007-969619

Planta Med 1984; 50(1): 47-52
DOI: 10.1055/s-2007-969619

Research Articles

Ein Oxepan-Derivat des Panaxadiols aus den Blättern von Panax notoginseng

An oxepane derivative of panaxadiol from the leaves of Panax notoginsengWei Junxiang¹ , Chang Liangyu¹ , Wang Jufen¹ , Chen Wei-shin¹ , Edmund Friedrichs² , Heinrich Puff² , Eberhard Breitmaier²

¹Yunnan Institute of Materia Medica, Academica Sinica, Kunming Yunnan, VR China
²Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str. 1, D-5300 Bonn 1

Abstract

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Abstract

Hydrolysis of the crude saponin isolated from the leaves of Panax notoginseng (Burk.) F. H. Chen yields five sapogenins which are separated by column chromatography. The structures of four of those were elucidated earlier to be panaxadiol, panaxatriol, dammar-20(22)en-3β, 12β,26-triol and 20(R)-dammaran-3β, 12β,20,25-tetrol. The fifth sapogenin is identified as an oxepane derivative probably arising from acid catalyzed dehydration and rearrangement of panaxadiol. The structure as proposed from NMR data was confirmed by single-crystal X-ray diffractometry.

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