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Planta Med 1985; 51(5): 424-427
DOI: 10.1055/s-2007-969538
DOI: 10.1055/s-2007-969538
Research Articles
© Georg Thieme Verlag Stuttgart · New York
Hypotensive Action of 3α-Dihydrocadambine, An Indole Alkaloid Glycoside of Uncaria Hooks [1]
Weitere Informationen
Publikationsverlauf
1985
1985
Publikationsdatum:
26. Februar 2007 (online)
Abstract
3α-Dihydrocadambine exhibited dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats. Its activity was much stronger and longer-lasting than that of rhynchophylline. In anesthetized dogs, it caused dilation of the vertebral, femoral and common carotid arteries, and had almost no effect on the coronary artery, whereas it had almost no significant activity in isolated canine arterial strip preparations.