Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung

Abstract

From the roots of Uncaria tomentosa six oxindol alkaloids have been isolated and identified as isopteropodin, pteropodin, mitraphyllin, isomitraphyllin, rynchophyllin and isorynchophyllin. By ion pair chromatography on HPLC a fingerprint analysis has been worked out which allowed to differentiate between various Unicaria-species and drug preparations. With the exception of mitraphyllin and rynchophyllin all alkaloids showed a pronounced enhancement effect on phagozytosis, determined in two in vitro tests and the in vivo-carbon clearance test.