Planta Med 1985; 51(3): 250-252
DOI: 10.1055/s-2007-969470
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Iso-Pimpinellin, ein Furanocumarin aus Heracleum sphondylium mit chromosomenschädigender Aktivität

Isopimpinellin - a furocoumarin from Heracleum sphondylium with chromosome damaging activityGudrun Abel1 , Clemens Erdelmeier2 , Beat Meier2 , Otto Sticher2
  • 1Institut für Botanik und Pharmazeutische Biologie der Universität Erlangen-Nürnberg, Schloßgarten 4, D-8520 Erlangen
  • 2Pharmazeutisches Institut, Eidgenössische Technische Hochschule Zürich, CH-8092 Zürich
Further Information

Publication History

1985

1985

Publication Date:
26 February 2007 (online)

Abstract

Effects on chromosomes were studied in human lymphocytes in vitro as a result of treatment by isopimpinellin plus UV-A. Isopimpinellin was isolated from Heracleum sphondylium with centrifugal accelerated layer chromatography (CLC). No induction of sister chromatid exchanges was found. Isopimpinellin plus UV-A exhibited, however, a weak clastogenic potency, which was expressed by an enhancement of the gap and break rates by a factor of 2 to 3. The relation between clastogenic and phototoxic activity of furocoumarins is critically discussed.

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