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Planta Med 1985; 51(3): 225-229
DOI: 10.1055/s-2007-969464
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Antibiotic Properties of Thiarubrine A, a Naturally Occurring Dithiacyclohexadiene Polyine

G. H. N. Towers, Z. Abramowski, A. J. Finlayson, A. Zucconi
  • Department of Botany, University of British Columbia, Vancouver, B. C., Canada V6T 2B1
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Publication History

1984

1985

Publication Date:
26 February 2007 (online)

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Abstract

Thiarubrine A, a dithiacyclohexadiene polyine from the roots of Chaenactis douglasii, exhibits strong antifungal activity towards Candida albicans and Aspergillus fumigatus at concentrations comparable to those of amphotericin B. It also exhibits cytotoxic activity towards Escherichia coli and Bacillus subtilis and the nematode Coenorhabditis elegans. A thiophene derived from thiarubrine A was shown to be phototoxic, requiring UV-A light for biological activity. The effects of thiarubrine A, thiophene A and α-terthienyl on the above organisms, as well as on CHO cells, were compared.